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TU Berlin

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Aude Bouchet

Lupe

“Molecular recognition between chiral molecules is known to govern the activity of biological systems such as bioenzymatic reactions or drug activity. My research consists in determining the structure of biorelevant chiral clusters and to characterize the specific interactions allowing for recognition.”

 

Scientific Career

Since 2017: Assistant Professor at Université de Lille Sciences et Technologies

2014–2016: IPODI Postdoctoral fellow, Technische Universität Berlin, Germany: Chiral recognition in ionic clusters of amino acids

2013–2014: Postdoctoral fellow, Technische Universität Berlin, Germany (DFG): Vibrational spectroscopy of protonated neurotransmitters in the gas phase

2012: Postdoctoral fellow, University Paris Sud, France (CNRS): Study of the formation of neutral chiral complexes by UV and IR spectroscopy in the gas phase

2008–2011: PhD in Physical Chemistry, University of Bordeaux 1, France: Study of the chiroptical properties of water soluble cryptophanes upon encapsulation of guest molecules

 

Research interests

  • Infrared and UV spectroscopy in the gas phase
  • Chirality
  • Molecular and ionic clusters
  • (Inter)molecular interactions

 

 

 

IPODI Research Project

Chiral Recognition in Ionic Clusters of Amino Acids (CARIOCA)

Duration: 1 May 2014 – 30 April 2016

Mentor: Prof. Dr. Otto Dopfer, Faculty II, Institut für Optik und Atomare Physik

Abstract: The CARIOCA project proposes a bottom-up approach for the understanding of the chiral recognition processes in biomolecules. Chiral recognition is well known to govern the activity of biological systems such as bioenzymatic reactions or drug activity. However, it is still poorly understood at the molecular level. In particular, the nature and the strength of intermolecular interactions responsible for the enantiospecificity are not described for ionic species, which are the most widespread in physiological media. Thus, CARIOCA aims at developing a new approach for the description of chiral preference occurring in biorelevant ionic assemblies by investigating chiral ionic clusters in the gas phase. Glutamic acid, one of the 22 natural amino acids, is a key molecule in life since it has numerous biological functions, notably as an essential neurotransmitter. It is also a small prototype system which allows for a very accurate description at the molecular level, both experimentally and theoretically. Isolated clusters of protonated glutamic acid, including bare ions, homo- and heterochiral larger clusters will be characterized in the gas phase by a large panel of outstanding state-of-the-art photophysical techniques coupled with mass spectrometry to characterize the intermolecular interactions responsible for chiral recognition in such ionic biomolecular building blocks, paying special attention to the effect of the local environment on the chiral recognition (solvent, metal).

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